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Long-Term Follow-up (>11 Years) on Successful Pregnancies With Ziconotide Monotherapy for Arachnoiditis-Related Chronic Pain

Published:October 26, 2022DOI:https://doi.org/10.1016/j.neurom.2022.05.008
      The inflammation in arachnoiditis may arise in response to several different stimuli, including central nervous system infections, surgical trauma, or spinal cord tumors. The initial inflammatory response is followed by the development of intrathecal (IT) adhesions that may disrupt the flow of the cerebrospinal fluid (CSF).
      • Killeen T.
      • Kamat A.
      • Walsh D.
      • Parker A.
      • Aliashkevich A.
      Severe adhesive arachnoiditis resulting in progressive paraplegia following obstetric spinal anaesthesia: a case report and review.
      Symptoms of arachnoiditis include lower back pain with radiating leg pain and neurological abnormalities. Magnetic resonance imaging (MRI) is used to confirm the presence of arachnoiditis.
      • Killeen T.
      • Kamat A.
      • Walsh D.
      • Parker A.
      • Aliashkevich A.
      Severe adhesive arachnoiditis resulting in progressive paraplegia following obstetric spinal anaesthesia: a case report and review.
      It is difficult to treat even with high-dose oral or topical opioids, or spinal cord stimulation, and often requires IT therapy.

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