The article by O’Connell et al, published in December 2021 in the Cochrane Database
of Systematic Reviews, presents a systematic review and meta-analysis of implanted
spinal neuromodulation therapies for the treatment of chronic pain.
1
The review is focused on spinal cord stimulation (SCS) and dorsal root ganglion stimulation
(DRGS). We agree that given the relative costs of SCS and DRGS and their invasive
nature, there is a need for rigorous review of their efficacy and safety, and we applaud
the authors for the rigorous work they have performed.Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe toAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Implanted spinal neuromodulation interventions for chronic pain in adults.Cochrane Database Syst Rev. 2021; 12CD013756
- The appropriate use of neurostimulation of the spinal cord and peripheral nervous system for the treatment of chronic pain and ischemic diseases: the Neuromodulation Appropriateness Consensus Committee.Neuromodulation. 2014; 17 ([discussion: 550]): 515-550
- Interventional management of neuropathic pain: NeuPSIG recommendations.Pain. 2013; 154: 2249-2261
- High quality of evidence is uncommon in Cochrane systematic reviews in Anaesthesia, Critical Care and Emergency Medicine.Eur J Anaesthesiol. 2017; 34: 808-813
- Reply to: quality of evidence in Cochrane systematic reviews in anaesthesia, critical care and emergency medicine.Eur J Anaesthesiol. 2018; 35: 637-638
- Cochrane reviews: four proposals for improvement.J Palliat Med. 2015; 18: 906-907
- Spinal cord stimulation versus reoperation for failed back surgery syndrome: a prospective, randomized study design.Acta Neurochir Suppl. 1995; 64: 106-108
- Spinal cord stimulation for chronic pain.Cochrane Database Syst Rev. 2004; 2004CD003783
- The effects of spinal cord stimulation in neuropathic pain are sustained: a 24-month follow-up of the prospective randomized controlled multicenter trial of the effectiveness of spinal cord stimulation.Neurosurgery. 2008; 63 ([discussion: 770]): 762-770
- Multicolumn spinal cord stimulation for predominant back pain in failed back surgery syndrome patients: a multicenter randomized controlled trial.Pain. 2019; 160: 1410-1420
- Efficacy of spinal cord stimulation as adjuvant therapy for intractable angina pectoris: a prospective, randomized clinical study. Working group on neurocardiology.J Am Coll Cardiol. 1994; 23: 1592-1597
- Effects of spinal cord stimulation (SCS) in patients with inoperable severe lower limb ischaemia: a prospective randomised controlled study.Eur J Vasc Endovasc Surg. 1995; 9: 421-425
- Spinal cord stimulation in chronic intractable angina pectoris: a randomized, controlled efficacy study.Am Heart J. 1998; 136: 1114-1120
- Electrical stimulation versus coronary artery bypass surgery in severe angina pectoris: the ESBY study.Circulation. 1998; 97: 1157-1163
- Spinal-cord stimulation in critical limb ischaemia: a randomised trial. ESES study group.Lancet. 1999; 353: 1040-1044
- Effect of spinal cord stimulation on spontaneous and stress-induced angina and ‘ischemia-like’ ST-segment depression in patients with cardiac syndrome X.Eur Heart J. 2005; 26: 983-989
- An open label, single-centre, randomized trial of spinal cord stimulation vs. percutaneous myocardial laser revascularization in patients with refractory angina pectoris: the SPiRiT trial.Eur Heart J. 2006; 27: 1048-1053
- Thoracic spinal cord stimulation improves functional status and relieves symptoms in patients with refractory angina pectoris: the first placebo-controlled randomised study.Heart. 2007; 93: 585-590
- Spinal cord stimulation for the treatment of refractory angina pectoris: a multicenter randomized single-blind study (the SCS-ITA trial).Pain. 2011; 152: 45-52
- Spinal cord stimulation therapy for patients with refractory angina who are not candidates for revascularization.Neuromodulation. 2012; 15 ([discussion: 558–559]): 550-558
- Novel 10-kHz high-frequency therapy (HF10 therapy) is superior to traditional low-frequency spinal cord stimulation for the treatment of chronic back and leg pain: the SENZA-RCT randomized controlled trial.Anesthesiology. 2015; 123: 851-860
- Comparison of 10-kHz high-frequency and traditional low-frequency spinal cord stimulation for the treatment of chronic back and leg pain: 24-month results from a multicenter, randomized, controlled pivotal trial.Neurosurgery. 2016; 79: 667-677
- Long-term quality of life improvement for chronic intractable back and leg pain patients using spinal cord stimulation: 12-month results from the SENZA-RCT.Qual Life Res. 2018; 27: 2035-2044
- Dorsal root ganglion stimulation yielded higher treatment success rate for complex regional pain syndrome and causalgia at 3 and 12 months: a randomized comparative trial.Pain. 2017; 158: 669-681
- Long-term safety and efficacy of closed-loop spinal cord stimulation to treat chronic back and leg pain (Evoke): a double-blind, randomised, controlled trial.Lancet Neurol. 2020; 19: 123-134
- Chapter 24: including non-randomized studies on intervention effects.in: Higgins J.P.T. Thomas J. Chandler J. Cochrane Handbook for Systematic Reviews of Interventions. Cochrane. 2021
- Chapter 14: Completing ‘Summary of findings’ tables and grading the certainty of the evidence.in: Higgins J.P.T. Thomas J. Chandler J. Cochrane Handbook for Systematic Reviews of Interventions. Cochrane. 2021
- Spinal cord stimulation in patients with chronic reflex sympathetic dystrophy.N Engl J Med. 2000; 343: 618-624
- The effect of spinal cord stimulation in patients with chronic reflex sympathetic dystrophy: two years' follow-up of the randomized controlled trial.Ann Neurol. 2004; 55: 13-18
- Effect of spinal cord stimulation for chronic complex regional pain syndrome type I: five-year final follow-up of patients in a randomized controlled trial.J Neurosurg. 2008; 108: 292-298
- Spinal cord stimulation for complex regional pain syndrome type I: a prospective cohort study with long-term follow-up.Neuromodulation. 2013; 16 ([discussion: 529]): 523-529
- Durability of clinical and quality-of-life outcomes of closed-loop spinal cord stimulation for chronic back and leg pain: a secondary analysis of the evoke randomized clinical trial.JAMA Neurol. 2022; 79: 251-260
- An analysis of the components of pain, function, and health-related quality of life in patients with failed back surgery syndrome treated with spinal cord stimulation or conventional medical management.Neuromodulation. 2010; 13: 201-209
- Summary of Safety and Effectiveness Data (SSED): Senza Spinal Cord Stimulation (SCS) System 2015.(Published online 2015. Accessed February 1, 2023.)
- Low-intensity, kilohertz frequency spinal cord stimulation differently affects excitatory and inhibitory neurons in the rodent superficial dorsal horn.Neuroscience. 2020; 428: 132-139
- Prospective, randomized, sham-control, double blind, crossover trial of subthreshold spinal cord stimulation at various kilohertz frequencies in subjects suffering from failed back surgery syndrome (SCS frequency study).Neuromodulation. 2018; 21: 457-465
- Analgesic efficacy of high-frequency spinal cord stimulation: a randomized double-blind placebo-controlled study.Neuromodulation. 2013; 16 ([discussion: 369]): 363-369
- Systematic review and meta-analysis of placebo/sham controlled randomised trials of spinal cord stimulation for neuropathic pain.Pain. 2020; 161: 24-35
- Is meta-analysis of RCTs assessing the efficacy of interventions a reliable source of evidence for therapeutic decisions?.Stud Hist Philos Sci. 2022; 91: 159-167
- N-of-1 trials can be aggregated to generate group mean treatment effects: a systematic review and meta-analysis.J Clin Epidemiol. 2016; 76: 65-75
- Comparison of aggregated N-of-1 trials with parallel and crossover randomized controlled trials using simulation studies.Healthcare (Basel). 2019; 7: 137
- Efficacy and safety of insulin in type 2 diabetes: meta-analysis of randomised controlled trials.BMC Endocr Disord. 2016; 16: 39
Comments
Article info
Publication history
Published online: April 06, 2023
Accepted:
March 5,
2023
Received in revised form:
March 1,
2023
Received:
January 31,
2023
Publication stage
In Press Corrected ProofFootnotes
Source(s) of financial support: The authors reported no funding sources.
Conflict of Interest: Marc A. Russo reports research activities (paid to research institution) for Boston Scientific, Mainstay Medical, Medtronic, Nevro, Presidio Medical, and Saluda Medical, historical equity interest in Stimwave, Lungpacer, and SPR Therapeutics, and stock options in Saluda Medical and Presidio Medical. He is President of the International Neuromodulation Society and Director-at-Large of the Neuromodulation Society of Australia and New Zealand. Anuj Bhatia reports research activities (paid to his hospital) for Medtronic. He has served as a consultant to Bioventus. Salim Hayek reports no conflict of interest. Tina Doshi reports research support (paid to institution) from the National Institutes of Health and consulting fees from Guidepoint Global. Sam Eldabe reports no conflict of interest. Frank Huygen reports independent investigator-initiated research grants (paid to hospital) from Abbott and Saluda Medical. He received honoraria for lectures at educational events sponsored by Abbott and Grunenthal. Robert M. Levy is an uncompensated consultant for Nalu, Saluda Medical, and Mainstay Medical and has stock options from Nalu and Saluda Medical obtained before 2019, not exercisable through the duration of his term as International Neuromodulation Society President and editor-in-chief of the journal Neuromodulation: Technology at the Neural Interface.
Identification
Copyright
© 2023 International Neuromodulation Society. Published by Elsevier Inc. All rights reserved.
