Abstract
Objective
The purpose of this study is to determine whether adaptively stepwise increasing the
intensity of a high-frequency (10 kHz) biphasic stimulation (HFBS) can produce nerve
conduction block without generating a large initial response.
Materials and Methods
In anesthetized cats, three cuff electrodes were implanted on the left pudendal nerve
for stimulation or block. The urethral pressure increase induced by pudendal nerve
stimulation was used to measure the pudendal nerve block induced by HFBS.
Results
HFBS applied suddenly with a large step increase in intensity induced a large (86 ±
16 cmH2O) urethral pressure increase before it blocked pudendal nerve conduction. However,
HFBS applied by adaptively stepwise increasing the intensity every 10 to 60 seconds
over a long period (33–301 minutes; average 108 ± 35 minutes) with many small intensity
increases (0.005–0.1 mA) induced no response or low-amplitude high-frequency urethral
pressure changes before it blocked pudendal nerve conduction. The minimal HFBS intensities
required by the two different methods to block pudendal nerve conduction are similar.
Conclusion
This study is important for better understanding the possible mechanisms underlying
the HFBS-induced nerve block and provides the possibility of developing a new nerve
block method for clinical applications in which an initial large response is a concern.
Keywords
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Comment
Article info
Publication history
Published online: April 29, 2023
Accepted:
March 29,
2023
Received in revised form:
March 14,
2023
Received:
January 23,
2023
Publication stage
In Press Corrected ProofFootnotes
Source(s) of financial support: This study is funded by the National Institute of Neurological Disorders and Stroke under Grant R01NS109198.
Conflict of Interest: Changfeng Tai is an inventor of a patent application related to this study. The remaining authors reported no conflict of interest.
Identification
Copyright
© 2023 International Neuromodulation Society. Published by Elsevier Inc. All rights reserved.
