Abstract
Background and Objective
Tibial nerve stimulation (TNS) has long been used to effectively treat lower urinary
tract dysfunction (LUTD). Although numerous studies have concentrated on TNS, its
mechanism of action remains elusive. This review aimed to concentrate on the mechanism
of action of TNS against LUTD.
Materials and Methods
A literature search was performed in PubMed on October 31, 2022. In this study, we
introduced the application of TNS for LUTD, summarized different methods used in exploring
the mechanism of TNS, and discussed the next direction to investigate the mechanism
of TNS.
Results and Conclusions
In this review, 97 studies, including clinical studies, animal experiments, and reviews,
were used. TNS is an effective treatment for LUTD. The study of its mechanisms primarily
concentrated on the central nervous system, tibial nerve pathway, receptors, and TNS
frequency. More advanced equipment will be used in human experiments to investigate
the central mechanism, and diverse animal experiments will be performed to explore
the peripheral mechanism and parameters of TNS in the future.
Keywords
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Comment
Article info
Publication history
Published online: May 12, 2023
Accepted:
March 31,
2023
Received in revised form:
March 3,
2023
Received:
December 8,
2022
Publication stage
In Press Corrected ProofFootnotes
Source(s) of financial support: This study was funded by the Ministry of Science and Technology of the People’s Republic of China (2018YFC2002203). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Conflict of Interest: The authors reported no conflict of interest.
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© 2023 International Neuromodulation Society. Published by Elsevier Inc. All rights reserved.
